siRNA Nanomedicine for Cancer Therapy
نویسندگان
چکیده
A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovascularization and tumor growth in animals with PC-3 tumor xenograft.
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تاریخ انتشار 2007